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Prof. Sarman Singh is a self-made person, who hails from a very small village of Aligarh, Uttar Pradesh. He always thought of doing some welfare work for the country, which benefits not only his community but all the poor and downtrodden. After obtaining MBBS degree from KGMC, Lucknow and MD from PGIMER, Chandigarh, in 1991, he joined the All India Institute of Medical Sciences, New Delhi as Assistant Professor. The Department he was assigned, had no research and development work and very few basic diagnostic services at that time. However, with his hard work, vision and seer perseverance his specialised division has now developed into a full fledged molecular biology centre of excellence which is very well equipped with most of the modern diagnostic and research tools such Whole Genome Sequencer, 6 laser flow cytometer, Molecular Biology work-station, MB-Bact, MGIT-960, Epicenter, various types of research and fluorescence microscopes, PCR, Real-time PCR, Mini-Mag,, NASBA, gel driers and DNA/RNA extractors, CO2 incubator, various types of centrifuges, biosafety cabinets, ELISA processors, electro-chemiluminescence, VIDAS etc.. The division is catering from very routine to most sophisticated molecular diagnostic services not only to the Institute hospital patients but also to patients of other hospitals in and outside Delhi. The laboratory has received several research grants from Department of Biotechnology, Indian Council of Medical Research, Department of Science and Technology, Council for Scientific and Industrial Research, NIH (USA), European Commission, Australia Council, Bill and Melinda Gates Foundation, WHO etc. Dr. Singh is voracious writer, dedicated researcher, loved teacher by his students, an able administrator and a visionary. This is evident from his high citation index of 6500, i10 index of 141 and h-index of 40. He is an internationally acclaimed medical scientist with outstanding research and academic achievements for his pioneering work in the field of infectious diseases. His work has made high impact on the society both directly and indirectly and saved thousands of lives from diseases and poverty. His contribution to the society has been in two ways: direct and immediate and indirect but long lasting. The immediate impact has been through his inventions and innovations in the field of two major killer infectious diseases- the kala-azar and tuberculosis. Though both diseases affect poor, but kala-azar mainly affects the poorest and down trodden (Singh et al, 2000). Thousands of poor in Bihar, West Bengal and Uttar Pradesh used to die due to kala-azar because the diagnostic methods were very costly for them to afford. The rapid test developed by his team which is highly cost-effective, the number of deaths due to kala-azar has come down. Though Government of India has taken several steps to tackle this disease, but the rapid test kit developed by him played pivotal role. His new inventions including the early diagnosis of tuberculosis and a mosquito proof cooler are on the way of commercialization which will make a dramatic change in the control of Tuberculosis and mosquito borne diseases. Indirect impact of his work has made a significant effect in youths and students across the country. Thousands of students get highly motivated after reading his biography (www.drsarmansingh.com). These youngsters generate confidence that with hard work, perseverance and honesty and scientists even poor students can also excel and contribute in the national building. The main focus of Prof. Sarman Singh's research has been on developing more sensitive and cost-effective diagnostic methods for infectious diseases, particularly those that are difficult to diagnose and treat. Towards this goal, he has made several ground breaking discoveries in the field of pathophysiology of visceral Leishmaniasis or kala-azar. He was the first to develop and patenting a rapid and highly cost-effective diagnostic test for this disease. A novel recombinant antigen (Ld-KE16) was prepared from an Indian strain of L. donovani (Singh & Sivakumar 2003; Sivakumar et al, 2006) ((PCT/IN2003/000400) and the commercial rights of the test were transferred to the M/s Span Diagnostic Pvt Ltd through the Department of Biotechnology, Govt. of India. The company has made rapid diagnostic test (RDT) kits in various test formats, which were dedicated to the nation by the Honourable Minister of Science & technology, Government of India Shri Kapil Sibal on February 6, 2006 in a glittering ceremony at the Press Club of India. These RDTs have made the invasive and hazardous methods like bone marrow and splenic aspiration dispensable at a very affordable price (Singh 2006). It is a matter of pride that the diagnosis of kala-azar can now be made at a cost of less than Rs. 50 per patient in India using these trailblazing "Made in India" kits. These test kits are exceptionally accurate with 100% specificity and 98% sensitivity. The disease kala-azar mainly affects the poor and down-trodden section of our society (Singh et al, 2000). Till rapid tests were made available, thousands of poor in the states of Bihar, W Bengal and Uttar Pradesh were dying due to this disease because of non-availability of sensitive, cost-effective and point-of-care diagnostic methods. It may be mentioned that with the availability of this revolutionary test, the number of kala-azar deaths has come down significantly - thanks to the Government of India for their active surveillance, and free treatment combined with the RDT kit developed by Dr. Singh that played a pivotal role in the national kala-azar elimination program. This cutting edge technology is also saving of millions of dollars of the Indian Government every year on foreign exchange. This is the first ever-indigenous invention by a medical scientist, which is become an integral part of any national disease elimination programme. This invention received high appreciation and applauds from the WHO (WR-India, as chair of the award selection committee) in the BMJ Research and Innovation excellence award distribution ceremony while announcing the award to Dr. Sarman Singh. Beside the above, this work has been recognised by the prominent science agencies of India, notably the Department of Biotechnology (Product, process and Commercialisation award); Indian Council of Medical Research (Dr. BK Aikat Award); Medical Council of India (Dr. BC Roy Award); Government of Uttar Pradesh (Vigyan Ratna Award); Indian Medical Association (Med-Achiever Award); Delhi Medical Association (Chikitsa Ratna Award); Indian Society of Parasitology (Dr. BP Pandey Oration Award); Indian Association of Tropical Parasitology (Outstanding Researcher in Parasitology); Indus Foundation (Innovation Excellence Award); Society for Immunology and Immunopathology (Life Time achievement Award) and many more. The issue of reservoirs of visceral leishmaniasis in India has remained dogmatic. The dictum has been that only post-kala-azar dermal leishmaniasis (PKDL) patients serve as reservoirs and there are no animal reservoirs in India, in contrast to the well-known animal reservoirs world-wide. In a spearheading study Dr. Singh working on the premise that in several areas where there are no PKDL cases (Dey et al, 2007), the outbreaks or sporadic cases of VL do occur (Singh et a, 2011). Furthermore, using novel PCR primers (PCT/IN2004/000395) his team also found that VL and PKDL strains are genetically different and both strains have differences in the anti-leishmanial drug susceptibility pattern (Mishra et al 2011). Therefore, in a radical approach, his team investigated thousands of animals in endemic areas as well as in non-endemic areas and found that goats are very potent animal reservoirs of VL in India (Singh et al 2013). These findings are bound to make drastic deviation in the kala-azar elimination programme of India. The whole genome sequence (WGS) of several isolates of Leishmania donovani from VL patients has been sequenced, but it is a matter of pride that Dr. Sarman Singh became the first in the world to carry out the WGS of the PKDL strain of L.During our test, drsarmansingh.com was downloaded in 0.0158 seconds. The homepage of the website is of 0.2285 Kb. The homepage was downloaded at the speed of 0.0141 Mbps, which is on the lower side.

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Microbiologist| Leishmaniasis| Toxoplasmosis| AIDS |

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